Reactome | Regorafenib-resistant PDGFR mutants

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authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
created	[InstanceEdit:9674407] Rothfels, Karen, 2020-01-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9674403
disease	[Disease:1500689] cancer
displayName	Regorafenib-resistant PDGFR mutants
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
eventOf	[Pathway:R-HSA-9674415] Drug resistance of PDGFR mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9674408] Regorafenib-resistant PDGFR mutants don't bind regorafenib - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671319] A precision therapy against cancers driven by KIT/PDGFRA mutations
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Regorafenib-resistant PDGFR mutants
normalPathway	[Pathway:R-HSA-186797] Signaling by PDGF
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9674403
summation	[Summation:9674409] Regorafenib is a type II TKI that is approved for the treatm...

(hasEvent)

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