Reactome | p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9673703] p-11Y VEGFR2(20-674)-PDGFRA(471-1089) fusion dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9673703] p-11Y VEGFR2(20-674)-PDGFRA(471-1089) fusion dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9673637] Rothfels, Karen, 2020-01-08
crossReference	[DatabaseIdentifier:12020790] Mondo:0018177
dbId	9673636
disease	[Disease:1247632] glioblastoma
displayName	p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
endCoordinate	662
hasModifiedResidue	[FragmentReplacedModification:9673615] Replacement of residues 662 to 662 by LVAGTWTSGLMSL [FragmentInsertionModification:9673612] Insertion of residues 471 to 1089 at 663 from UniProt:P16234 PDGFRA [ModifiedResidue:186764] O4'-phospho-L-tyrosine at 1018 [ModifiedResidue:186779] O4'-phospho-L-tyrosine at 572 [ModifiedResidue:186787] O4'-phospho-L-tyrosine at 574 [ModifiedResidue:186796] O4'-phospho-L-tyrosine at 720 [ModifiedResidue:186782] O4'-phospho-L-tyrosine at 731 [ModifiedResidue:186809] O4'-phospho-L-tyrosine at 742 [ModifiedResidue:186771] O4'-phospho-L-tyrosine at 754 [ModifiedResidue:186823] O4'-phospho-L-tyrosine at 762 [ModifiedResidue:186775] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:186801] O4'-phospho-L-tyrosine at 988 [ModifiedResidue:389089] O4'-phospho-L-tyrosine at 849
inDisease	true
literatureReference	[LiteratureReference:9673553] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
maxDepth	1
modified	[InstanceEdit:9832522] Orlic-Milacic, Marija, 2023-04-02
name	p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) Vascular endothelial growth factor receptor 2 VGFR2_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P35968] UniProt:P35968 KDR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9673636
startCoordinate	20
updateTrackers	[UpdateTracker:9905512] Update Tracker - [EntityWithAccessionedSequence:9673636] p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] - v85:[modifyEndCoordinate, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905512] Update Tracker - [EntityWithAccessionedSequence:9673636] p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] - v85:[modifyEndCoordinate, modifyName]
(hasComponent)	[Complex:R-HSA-9673703] p-11Y VEGFR2(20-674)-PDGFRA(471-1089) fusion dimer [plasma membrane]

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