Reactome | VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9673670] VEGFR2(20-674)-PDGFRA(471-1089) fusion dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9673614] Rothfels, Karen, 2020-01-08
dbId	9673613
disease	[Disease:1247632] glioblastoma multiforme
displayName	VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
endCoordinate	662
hasModifiedResidue	[FragmentReplacedModification:9673615] Replacement of residues 662 to 662 by LVAGTWTSGLMSL [FragmentInsertionModification:9673612] Insertion of residues 471 to 1089 at 663 from UniProt:P16234 PDGFRA
inDisease	true
literatureReference	[LiteratureReference:9673553] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
memberOf	[CandidateSet:R-HSA-9673677] membrane-tethered PDGFR fusions [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832522] Orlic-Milacic, Marija, 2023-04-02
name	VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion Vascular endothelial growth factor receptor 2 VGFR2_HUMAN
referenceEntity	[ReferenceGeneProduct:67174] UniProt:P35968 KDR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9673613
startCoordinate	20

(hasMember)	[CandidateSet:R-HSA-9673677] membrane-tethered PDGFR fusions [plasma membrane]
(hasComponent)	[Complex:R-HSA-9673670] VEGFR2(20-674)-PDGFRA(471-1089) fusion dimer [plasma membrane]

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