Reactome | p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]

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p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane
componentOf	[Complex:R-HSA-9672047] p-11Y PDGFRA Y288C dimer [endoplasmic reticulum membrane] - Homo sapiens
created	[InstanceEdit:9672028] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:9671946] COSMIC:COSM7002240 [DatabaseIdentifier:9671947] COSMIC:COSV57264810
dbId	9672027
disease	[Disease:1500689] cancer [Disease:1996318] astrocytoma
displayName	p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9671923] L-tyrosine 288 replaced with L-cysteine [ModifiedResidue:186764] O4'-phospho-L-tyrosine at 1018 [ModifiedResidue:186779] O4'-phospho-L-tyrosine at 572 [ModifiedResidue:186787] O4'-phospho-L-tyrosine at 574 [ModifiedResidue:186796] O4'-phospho-L-tyrosine at 720 [ModifiedResidue:186782] O4'-phospho-L-tyrosine at 731 [ModifiedResidue:186809] O4'-phospho-L-tyrosine at 742 [ModifiedResidue:186771] O4'-phospho-L-tyrosine at 754 [ModifiedResidue:186823] O4'-phospho-L-tyrosine at 762 [ModifiedResidue:186775] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:186801] O4'-phospho-L-tyrosine at 988 [ModifiedResidue:389089] O4'-phospho-L-tyrosine at 849
inDisease	true
literatureReference	[LiteratureReference:9671886] Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
name	p-11Y PDGFRA Y288C Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:61602] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9672027
startCoordinate	24

Referrals

(hasComponent)

[Complex:R-HSA-9672047] p-11Y PDGFRA Y288C dimer [endoplasmic reticulum membrane]

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