Reactome | p-10Y PDGFRA Y849C [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-10Y PDGFRA Y849C [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9672048] p-10Y PDGFRA Y849C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9672048] p-10Y PDGFRA Y849C dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9671976] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719 [DatabaseIdentifier:9671953] COSMIC:COSV57267031 [DatabaseIdentifier:9671938] COSMIC:COSM19369
dbId	9671977
disease	[Disease:1500689] cancer [Disease:9661830] gastrointestinal stromal tumor [Disease:1996318] astrocytoma [Disease:1655494] prostate adenocarcinoma
displayName	p-10Y PDGFRA Y849C [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9671926] L-tyrosine 849 replaced with L-cysteine [ModifiedResidue:186764] O4'-phospho-L-tyrosine at 1018 [ModifiedResidue:186779] O4'-phospho-L-tyrosine at 572 [ModifiedResidue:186787] O4'-phospho-L-tyrosine at 574 [ModifiedResidue:186796] O4'-phospho-L-tyrosine at 720 [ModifiedResidue:186782] O4'-phospho-L-tyrosine at 731 [ModifiedResidue:186809] O4'-phospho-L-tyrosine at 742 [ModifiedResidue:186771] O4'-phospho-L-tyrosine at 754 [ModifiedResidue:186823] O4'-phospho-L-tyrosine at 762 [ModifiedResidue:186775] O4'-phospho-L-tyrosine at 768 [ModifiedResidue:186801] O4'-phospho-L-tyrosine at 988
inDisease	true
literatureReference	[LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib
maxDepth	1
name	p-10Y PDGFRA Y849C Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9671977
startCoordinate	24

Referrals

(hasComponent)

[Complex:R-HSA-9672048] p-10Y PDGFRA Y849C dimer [plasma membrane]

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