Reactome | PDGFRA V536E [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9672062] PDGFRA V536E dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9672062] PDGFRA V536E dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9671965] Rothfels, Karen, 2019-12-23
crossReference	[DatabaseIdentifier:12021113] Mondo:0021636 [DatabaseIdentifier:9671943] COSMIC:COSV57271679
dbId	9671964
disease	[Disease:1500689] cancer [Disease:1996318] astrocytoma
displayName	PDGFRA V536E [plasma membrane]
endCoordinate	1089
hasModifiedResidue	[ReplacedResidue:9671927] L-valine 536 replaced with L-glutamic acid
inDisease	true
literatureReference	[LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations
maxDepth	1
memberOf	[CandidateSet:R-HSA-9672133] transmembrane domain PDGFRA mutants [plasma membrane] - Homo sapiens
name	PDGFRA V536E Alpha platelet-derived growth factor receptor PGDS_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:P16234] UniProt:P16234 PDGFRA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9671964
startCoordinate	24

(hasMember)	[CandidateSet:R-HSA-9672133] transmembrane domain PDGFRA mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9672062] PDGFRA V536E dimer [plasma membrane]

Cite Us!