Reactome | Defective DAXX does not bind ATRX

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Defective DAXX does not bind ATRX Show undefined attributes

authored	[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020-04-30
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9670612] Orlic-Milacic, Marija, 2019-12-11
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670620
disease	[Disease:1500689] cancer
displayName	Defective DAXX does not bind ATRX
edited	[InstanceEdit:9706939] Orlic-Milacic, Marija, 2020-11-09 [InstanceEdit:9707388] Orlic-Milacic, Marija, 2020-11-16
entityFunctionalStatus	[EntityFunctionalStatus:9670617] loss_of_function of DAXX Truncation Mutants (N-terminus) [nucleoplasm]
eventOf	[Pathway:R-HSA-9670613] Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9007919] ATRX [nucleoplasm] [CandidateSet:R-HSA-9670611] DAXX Truncation Mutants (N-terminus) [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9672765] Structural basis for DAXX interaction with ATRX [LiteratureReference:9671773] A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective DAXX does not bind ATRX
normalReaction	[Reaction:R-HSA-9007926] ATRX binds DAXX
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706941] Meeker, Alan K, 2020-11-05 [InstanceEdit:9707389] Reddel, Roger R, 2020-11-13
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670620
summation	[Summation:9672767] DAXX mutations identified in cancer are frequently nonsense ...

Referrals

(hasEvent)

[Pathway:R-HSA-9670613] Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations

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