Reactome | FVIIIa variants [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
consumedByEvent	[FailedReaction:R-HSA-9670189] F8 variant does not bind the cell membrane - Homo sapiens
created	[InstanceEdit:9670195] Shamovsky, Veronica, 2019-12-06
crossReference	[DatabaseIdentifier:12020814] Mondo:0010602
dbId	9670192
disease	[Disease:9661959] factor VIII deficiency
displayName	FVIIIa variants [extracellular region]
hasComponent	[DefinedSet:R-HSA-9670218] F8 A3-C1-C2 variants defective in phospholipid binding. [extracellular region] [EntityWithAccessionedSequence:R-HSA-158290] F8(20-391) [extracellular region] [EntityWithAccessionedSequence:R-HSA-158199] F8(392-759) [extracellular region]
inDisease	true
literatureReference	[LiteratureReference:9670207] Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding [LiteratureReference:9665821] Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities
maxDepth	3
modified	[InstanceEdit:9676354] Shamovsky, Veronica, 2020-02-13
name	FVIIIa variants factor VIIIa variants with defective C2 domain
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9670192

(input)	[FailedReaction:R-HSA-9670189] F8 variant does not bind the cell membrane
(diseaseEntity)	[EntityFunctionalStatus:9670212] loss_of_function of FVIIIa variants [extracellular region]

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