Reactome | factor VIIIa with defective A1 domain [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
consumedByEvent	[Reaction:R-HSA-9670049] Defects in F8 A1 domain accelerate dissociation of the A2 domain - Homo sapiens
created	[InstanceEdit:9670053] Shamovsky, Veronica, 2019-12-04
crossReference	[DatabaseIdentifier:12020814] Mondo:0010602
dbId	9670038
disease	[Disease:9661959] factor VIII deficiency
displayName	factor VIIIa with defective A1 domain [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-HSA-158271] F8(1709-2351) [extracellular region] [DefinedSet:R-HSA-9670040] F8(20-372) variant [extracellular region] [EntityWithAccessionedSequence:R-HSA-158199] F8(392-759) [extracellular region]
inDisease	true
maxDepth	3
name	factor VIIIa with defective A1 domain FVIIIa A1 domain variant
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9670038

(input)	[Reaction:R-HSA-9670049] Defects in F8 A1 domain accelerate dissociation of the A2 domain
(diseaseEntity)	[EntityFunctionalStatus:9670057] gain_of_function of factor VIIIa with defective A1 domain [extracellular region]

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