Reactome | p7Y-KIT D816V [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p7Y-KIT D816V [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9669599] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:9669331] COSMIC:COSV55386424 [DatabaseIdentifier:9669343] COSMIC:COSM28677
dbId	9669612
disease	[Disease:1500689] cancer [Disease:1614289] melanoma [Disease:9630839] acute myeloid leukemia [Disease:9669013] mast cell neoplasm
displayName	p7Y-KIT D816V [plasma membrane]
endCoordinate	976
hasModifiedResidue	[ReplacedResidue:9669502] L-aspartic acid 816 replaced with L-valine [ModifiedResidue:205176] O4'-phospho-L-tyrosine at 568 [ModifiedResidue:205169] O4'-phospho-L-tyrosine at 570 [ModifiedResidue:205278] O4'-phospho-L-tyrosine at 703 [ModifiedResidue:205171] O4'-phospho-L-tyrosine at 721 [ModifiedResidue:205288] O4'-phospho-L-tyrosine at 730 [ModifiedResidue:205235] O4'-phospho-L-tyrosine at 823 [ModifiedResidue:205246] O4'-phospho-L-tyrosine at 936
inDisease	true
literatureReference	[LiteratureReference:9669155] Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
memberOf	[CandidateSet:R-HSA-9669820] p7Y-kinase domain KIT mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9766312] D'Eustachio, Peter, 2022-02-18
name	p7Y-KIT D816V Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT
referenceEntity	[ReferenceGeneProduct:58103] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9669612
startCoordinate	26

Referrals

(hasMember)

[CandidateSet:R-HSA-9669820] p7Y-kinase domain KIT mutants [plasma membrane]

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