Reactome | p-7Y-KIT K550I;P551_V555del [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-7Y-KIT K550I;P551_V555del [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9669775] p7Y-KIT K550I P551_V555del dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9669775] p7Y-KIT K550I P551_V555del dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9669599] Rothfels, Karen, 2019-12-03
crossReference	[DatabaseIdentifier:12020834] Mondo:0011719
dbId	9669602
disease	[Disease:9661830] gastrointestinal stromal tumor [Disease:1500689] cancer
displayName	p-7Y-KIT K550I;P551_V555del [plasma membrane]
endCoordinate	976
hasModifiedResidue	[ReplacedResidue:9669442] L-lysine 550 replaced with L-isoleucine [FragmentDeletionModification:9669439] Deletion of residues 551 to 555 [ModifiedResidue:205176] O4'-phospho-L-tyrosine at 568 [ModifiedResidue:205169] O4'-phospho-L-tyrosine at 570 [ModifiedResidue:205278] O4'-phospho-L-tyrosine at 703 [ModifiedResidue:205171] O4'-phospho-L-tyrosine at 721 [ModifiedResidue:205288] O4'-phospho-L-tyrosine at 730 [ModifiedResidue:205235] O4'-phospho-L-tyrosine at 823 [ModifiedResidue:205246] O4'-phospho-L-tyrosine at 936
inDisease	true
literatureReference	[LiteratureReference:9669122] Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
maxDepth	1
modified	[InstanceEdit:9832451] Orlic-Milacic, Marija, 2023-04-01
name	p-7Y-KIT K550I;P551_V555del Mast/stem cell growth factor receptor precursor KIT_HUMAN c-KIT
referenceEntity	[ReferenceGeneProduct:uniprot:P10721] UniProt:P10721 KIT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9669602
startCoordinate	26
updateTrackers	[UpdateTracker:9905365] Update Tracker - [EntityWithAccessionedSequence:9669602] p-7Y-KIT K550I;P551_V555del [plasma membrane] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905365] Update Tracker - [EntityWithAccessionedSequence:9669602] p-7Y-KIT K550I;P551_V555del [plasma membrane] - v85:[modifyName]
(hasComponent)	[Complex:R-HSA-9669775] p7Y-KIT K550I P551_V555del dimer [plasma membrane]

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