Reactome | F8 variant is not sulfonated at Y1699

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F8 variant is not sulfonated at Y1699 Show undefined attributes

authored	[InstanceEdit:9660568] Shamovsky, Veronica, 2019-09-09
catalystActivity	[CatalystActivity:8954238] protein-tyrosine sulfotransferase activity of TPST1,2 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9668147] Shamovsky, Veronica, 2019-11-19
crossReference	[DatabaseIdentifier:12020814] Mondo:0010602
dbId	9668148
disease	[Disease:9661959] factor VIII deficiency
displayName	F8 variant is not sulfonated at Y1699
edited	[InstanceEdit:9690131] Shamovsky, Veronica, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9668272] loss_of_function of F8 Y1699F [Golgi lumen]
eventOf	[Pathway:R-HSA-9674519] Defective F8 sulfation at Y1699 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9668150] F8 Y1699F [Golgi lumen] 2 × [SimpleEntity:R-ALL-741440] PAPS [Golgi lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9668041] Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII [LiteratureReference:9668032] Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage [LiteratureReference:9668020] Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	F8 variant is not sulfonated at Y1699
normalReaction	[Reaction:R-HSA-9668023] TPST1,2 transfer SO4(2-) from PAPS to FVIII
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9673821] D'Eustachio, Peter, 2020-01-09 [InstanceEdit:9681505] Zhang, Bin, 2020-04-02
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9668148
summation	[Summation:9668149] Post-translational cellular processing of the factor VIII (F...

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[Pathway:R-HSA-9674519] Defective F8 sulfation at Y1699

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