Reactome | p-6Y-ERBB2 V659E [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665888] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:9667215] COSMIC:COSV54062460 [DatabaseIdentifier:9667216] COSMIC:COSV54065138
dbId	9665874
disease	[Disease:1500689] cancer [Disease:2327989] bile duct carcinoma [Disease:8853117] lung adenocarcinoma [Disease:1247848] non-small cell lung carcinoma
displayName	p-6Y-ERBB2 V659E [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9665762] L-valine 659 replaced with L-glutamic acid [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease	true
literatureReference	[LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
modified	[InstanceEdit:9667217] Orlic-Milacic, Marija, 2019-11-08
name	p-6Y-ERBB2 V659E
referenceEntity	[ReferenceGeneProduct:54422] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9665874
startCoordinate	23

(hasCandidate)

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