Reactome | p-6Y-ERBB2 G660D [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-9665884] p-6Y-ERBB2 TMD/JMD mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665888] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9667240] COSMIC:COSV54064554
dbId	9665866
disease	[Disease:1500689] cancer [Disease:2327989] bile duct carcinoma [Disease:1493885] bladder carcinoma [Disease:1248674] large intestine cancer [Disease:2328198] pancreatic cancer
displayName	p-6Y-ERBB2 G660D [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9665765] glycine 660 replaced with L-aspartic acid [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease	true
literatureReference	[LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
maxDepth	1
modified	[InstanceEdit:9667242] Orlic-Milacic, Marija, 2019-11-08
name	p-6Y-ERBB2 G660D
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9665866
startCoordinate	23

(hasCandidate)

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