Reactome | ERBB2 Q709L [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-9665885] ERBB2 TMD/JMD mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:12021318] Mondo:0004669 [DatabaseIdentifier:9667244] COSMIC:COSV54072619 [DatabaseIdentifier:9667243] COSMIC:COSM5985654
dbId	9665770
disease	[Disease:1500689] cancer [Disease:8853117] lung adenocarcinoma [Disease:1655480] salivary gland cancer
displayName	ERBB2 Q709L [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9665764] L-glutamine 709 replaced with L-leucine
inDisease	true
literatureReference	[LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
maxDepth	1
memberOf	[DefinedSet:R-HSA-9665964] ERBB2 TMD/JMD mutants (pertuzumab resistant) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665934] ERBB2 TMD/JMD mutants (neratinib) [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9667246] Orlic-Milacic, Marija, 2019-11-08
name	ERBB2 Q709L
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9665770
startCoordinate	23

(hasMember)	[DefinedSet:R-HSA-9665964] ERBB2 TMD/JMD mutants (pertuzumab resistant) [plasma membrane] [DefinedSet:R-HSA-9665934] ERBB2 TMD/JMD mutants (neratinib) [plasma membrane] [DefinedSet:R-HSA-9665935] ERBB2 TMD/JMD mutants (afatinib) [plasma membrane] [DefinedSet:R-HSA-9665955] ERBB2 TMD/JMD mutants (trastuzumab) [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-9665885] ERBB2 TMD/JMD mutants [plasma membrane]

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