Reactome | ERBB2 R678Q [plasma membrane]

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9665973] ERBB2 R678Q:pertuzumab [plasma membrane] - Homo sapiens [Complex:R-HSA-9665968] ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane] - Homo sapiens
created	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:12021317] Mondo:0005517 [DatabaseIdentifier:9667200] COSMIC:COSM6907329 [DatabaseIdentifier:9667202] COSMIC:COSV54062926
dbId	9665756
disease	[Disease:1500689] cancer [Disease:2317358] endometrial cancer [Disease:2327989] bile duct carcinoma [Disease:9630851] gallbladder adenocarcinoma [Disease:1500576] breast cancer [Disease:1614672] cervical cancer [Disease:1248674] large intestine cancer [Disease:9632339] esophagus adenocarcinoma [Disease:9630862] esophagus squamous cell carcinoma [Disease:9630864] pancreatic ductal adenocarcinoma [Disease:1614291] rhabdomyosarcoma [Disease:3310977] small intestine carcinoma [Disease:1500687] stomach cancer [Disease:9632618] nasopharynx carcinoma [Disease:2327997] pharynx cancer [Disease:1493885] bladder carcinoma
displayName	ERBB2 R678Q [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9665758] L-arginine 678 replaced with L-glutamine
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations [LiteratureReference:9665999] Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib
maxDepth	1
memberOf	[DefinedSet:R-HSA-9665933] ERBB2 TMD/JMD mutants (lapatinib) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665935] ERBB2 TMD/JMD mutants (afatinib) [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9667217] Orlic-Milacic, Marija, 2019-11-08
name	ERBB2 R678Q
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9665756
startCoordinate	23

(hasMember)	[DefinedSet:R-HSA-9665933] ERBB2 TMD/JMD mutants (lapatinib) [plasma membrane] [DefinedSet:R-HSA-9665934] ERBB2 TMD/JMD mutants (neratinib) [plasma membrane] [DefinedSet:R-HSA-9665935] ERBB2 TMD/JMD mutants (afatinib) [plasma membrane] [DefinedSet:R-HSA-9665955] ERBB2 TMD/JMD mutants (trastuzumab) [plasma membrane] [CandidateSet:R-HSA-9665885] ERBB2 TMD/JMD mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9665973] ERBB2 R678Q:pertuzumab [plasma membrane] [Complex:R-HSA-9665968] ERBB2 R678Q:ERBIN:HSP90:CDC37 [plasma membrane]

ERBB2 R678Q [plasma membrane] Show undefined attributes

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