Reactome | Some pathogenic BRCA1 mutants do not bind BARD1

Schema > FailedReaction > Entries

Some pathogenic BRCA1 mutants do not bind BARD1 Show undefined attributes

authored	[InstanceEdit:9702562] Orlic-Milacic, Marija, 2020-09-30
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9663197] Orlic-Milacic, Marija, 2019-09-27
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9663194
disease	[Disease:1500689] cancer
displayName	Some pathogenic BRCA1 mutants do not bind BARD1
edited	[InstanceEdit:9706872] Orlic-Milacic, Marija, 2020-11-09
entityFunctionalStatus	[EntityFunctionalStatus:9663211] loss_of_function of BRCA1 mutants (BARD1 binding) [nucleoplasm]
eventOf	[Pathway:R-HSA-9663199] Defective DNA double strand break response due to BRCA1 loss of function - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5659775] BARD1 [nucleoplasm] [CandidateSet:R-HSA-9663193] BRCA1 mutants (BARD1 binding) [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9663191] Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination [LiteratureReference:5659818] Characterization of an Italian founder mutation in the RING-finger domain of BRCA1 [LiteratureReference:5659810] Identification of a RING protein that can interact in vivo with the BRCA1 gene product [LiteratureReference:9700977] BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions [LiteratureReference:5659825] Structure of a BRCA1-BARD1 heterodimeric RING-RING complex
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Some pathogenic BRCA1 mutants do not bind BARD1
normalReaction	[Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706944] Baer, Richard J, 2020-11-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9663194
summation	[Summation:9700976] The heterodimerization of BRCA1 and BARD1 is mediated by seq...

Referrals

(hasEvent)

[Pathway:R-HSA-9663199] Defective DNA double strand break response due to BRCA1 loss of function

Cite Us!