Reactome | Bacterial GUSB hydrolyses BDG to BIL

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Bacterial GUSB hydrolyses BDG to BIL Show undefined attributes

authored	[InstanceEdit:9661819] Jassal, Bijay, 2019-09-19
catalystActivity	[CatalystActivity:9661510] hydrolase activity, hydrolyzing O-glycosyl compounds of GUSB [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9661819] Jassal, Bijay, 2019-09-19
dbId	9661820
displayName	Bacterial GUSB hydrolyses BDG to BIL
edited	[InstanceEdit:9661819] Jassal, Bijay, 2019-09-19
eventOf	[Pathway:R-HSA-189483] Heme degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9661745] An unknown BILR reduces BIL to D-UBGN - Homo sapiens
input	[SimpleEntity:R-ALL-5679019] BDG [extracellular region] 2 × [SimpleEntity:R-ALL-109276] H2O [extracellular region] 3 × [SimpleEntity:R-ALL-351627] NADPH [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9661479] Purification and characterization of beta-glucuronidase from Escherichia coli HGU-3, a human intestinal bacterium [LiteratureReference:9661489] Expression of bacterial beta-glucuronidase in human bile: an in vitro study [LiteratureReference:9661505] [Bilirubin metabolism (author's transl)]
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Bacterial GUSB hydrolyses BDG to BIL
output	[SimpleEntity:R-ALL-9661418] BIL [extracellular region] 2 × [SimpleEntity:R-ALL-9661481] GlcA [extracellular region] 3 × [SimpleEntity:R-ALL-351628] NADP+ [extracellular region]
precedingEvent	[Reaction:R-HSA-5679041] ABCC2 transports BMG,BDG from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9661417] ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region - Homo sapiens
relatedSpecies	[Species:9661522] Clostridium perfringens
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9663548] D'Eustachio, Peter, 2019-10-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9661820
summation	[Summation:9661499] Bilirubin diglucuronide (BDG) is a substrate for microbial ?...

Referrals

(hasEvent)	[Pathway:R-HSA-189483] Heme degradation
(precedingEvent)	[BlackBoxEvent:R-HSA-9661745] An unknown BILR reduces BIL to D-UBGN [NegativePrecedingEvent:9955854] Bacterial GUSB hydrolyses BDG to BIL [NegativePrecedingEvent:9955858] Bacterial GUSB hydrolyses BDG to BIL [NegativePrecedingEvent:9955859] Bacterial GUSB hydrolyses BDG to BIL [NegativePrecedingEvent:9955844] Bacterial GUSB hydrolyses BDG to BIL

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