Reactome | p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-9656156] activated RAF1 CR3 mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9656032] Rothfels, Karen, 2019-07-27
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9655966] COSMIC:COSV52579684 [DatabaseIdentifier:9655968] ClinGen:CA351507100 [DatabaseIdentifier:9655977] ClinGen:CA351507098
dbId	9656031
disease	[Disease:4791250] colorectal cancer
displayName	p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
endCoordinate	648
hasModifiedResidue	[ModifiedResidue:109785] O-phospho-L-serine at 621 [ReplacedResidue:9655940] glycine 370 replaced with L-arginine [ModifiedResidue:444234] O-phospho-L-serine at 338 [ModifiedResidue:109791] O4'-phospho-L-tyrosine at 341 [ModifiedResidue:5672662] O-phospho-L-threonine at 491 [ModifiedResidue:5672663] O-phospho-L-serine at 494
inDisease	true
maxDepth	1
name	p-S338,Y341,T492,S494,S621 RAF1 G370R RAF proto-oncogene serine/threonine-protein kinase Raf-1 C-RAF cRaf
referenceEntity	[ReferenceGeneProduct:uniprot:P04049] UniProt:P04049 RAF1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9656031
startCoordinate	1

(hasCandidate)

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