Reactome | Calmodulin dissociates KRAS4B from the plasma membrane

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Calmodulin dissociates KRAS4B from the plasma membrane Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9654522] Rothfels, Karen, 2019-07-18
dbId	9654521
displayName	Calmodulin dissociates KRAS4B from the plasma membrane
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-9648002] RAS processing - Homo sapiens
followingEvent	[Reaction:R-HSA-9654525] PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ - Homo sapiens
input	[Complex:R-HSA-9653583] S-Farn-Me KRAS4B:CALM1:4xCa2+ [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9653567] Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin [LiteratureReference:9653555] Ca2+/calmodulin binds and dissociates K-RasB from membrane [LiteratureReference:9654504] Regulation of K-Ras4B Membrane Binding by Calmodulin [LiteratureReference:9654499] RAS Proteins and Their Regulators in Human Disease
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Calmodulin dissociates KRAS4B from the plasma membrane
orthologousEvent	[BlackBoxEvent:R-RNO-9654521] Calmodulin dissociates KRAS4B from the plasma membrane - Rattus norvegicus [BlackBoxEvent:R-CEL-9654521] Calmodulin dissociates KRAS4B from the plasma membrane - Caenorhabditis elegans [BlackBoxEvent:R-DME-9654521] Calmodulin dissociates KRAS4B from the plasma membrane - Drosophila melanogaster [BlackBoxEvent:R-BTA-9654521] Calmodulin dissociates KRAS4B from the plasma membrane - Bos taurus [BlackBoxEvent:R-CFA-9654521] Calmodulin dissociates KRAS4B from the plasma membrane - Canis familiaris [BlackBoxEvent:R-MMU-9654521] Calmodulin dissociates KRAS4B from the plasma membrane - Mus musculus
output	[Complex:R-HSA-9654512] S-Farn-Me KRAS4B:CALM1:4xCa2+ [cytosol]
precedingEvent	[Reaction:R-HSA-9653585] S-Farn-Me KRAS4B binds calmodulin - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9654521
summation	[Summation:9654527] Ca2+/calmodulin-binding to KRAS4B dissociates it from the pl...

Referrals

(hasEvent)	[Pathway:R-HSA-9648002] RAS processing
(precedingEvent)	[Reaction:R-HSA-9654525] PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+

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