Reactome | p-Y-ERBB2 I767M [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-Y-ERBB2 I767M [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9654310] Orlic-Milacic, Marija, 2019-07-18
crossReference	[DatabaseIdentifier:12021318] Mondo:0004669 [DatabaseIdentifier:9646736] COSMIC:COSV54064925 [DatabaseIdentifier:9646738] COSMIC:COSM4422821
dbId	9654303
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:9630862] esophagus squamous cell carcinoma [Disease:1500575] ovarian cancer [Disease:6802273] skin melanoma [Disease:1493885] bladder carcinoma [Disease:9632618] nasopharynx carcinoma [Disease:1655480] salivary gland cancer
displayName	p-Y-ERBB2 I767M [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646735] L-isoleucine 767 replaced with L-methionine [ModifiedResidue:1678588] O4'-phospho-L-tyrosine at unknown position
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9646758] Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
maxDepth	1
memberOf	[CandidateSet:R-HSA-9664656] p-Y-ERBB2 KD mutants (ERBB3,PI3K) [plasma membrane] - Homo sapiens
name	p-Y-ERBB2 I767M p-Y-HER2 I767M p-Y-ERBB2 Ile767Met p-Y-HER2 Ile767Met
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9654303
startCoordinate	23

Referrals

(hasMember)

[CandidateSet:R-HSA-9664656] p-Y-ERBB2 KD mutants (ERBB3,PI3K) [plasma membrane]

© 2026 Reactome

Cite Us!