Reactome | pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane

Schema > BlackBoxEvent > Entries

pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	omitted
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9653593] Rothfels, Karen, 2019-07-11
dbId	9653592
displayName	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-9648002] RAS processing - Homo sapiens
followingEvent	[Reaction:R-HSA-9653595] pS181-S-Farn-Me KRAS4B binds BCL2L1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9653482] pS181-S-Farn-Me KRAS4B [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9653428] PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis [LiteratureReference:9653411] Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region [LiteratureReference:9653421] Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status [LiteratureReference:9653444] Posttranslational Modifications of RAS Proteins
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane
orthologousEvent	[BlackBoxEvent:R-RNO-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Rattus norvegicus [BlackBoxEvent:R-DDI-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Dictyostelium discoideum [BlackBoxEvent:R-CEL-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Caenorhabditis elegans [BlackBoxEvent:R-DME-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Drosophila melanogaster [BlackBoxEvent:R-DRE-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Danio rerio [BlackBoxEvent:R-SSC-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Sus scrofa [BlackBoxEvent:R-BTA-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Bos taurus [BlackBoxEvent:R-CFA-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Canis familiaris [BlackBoxEvent:R-MMU-9653592] pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9653578] pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-9653503] KRAS4B is phosphorylated on serine 181 - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9653592
summation	[Summation:9653582] PKC- or -PRKG2-dependent phosphorylation of KRAS4B at serine...

Referrals

(hasEvent)	[Pathway:R-HSA-9648002] RAS processing
(precedingEvent)	[Reaction:R-HSA-9653595] pS181-S-Farn-Me KRAS4B binds BCL2L1