Reactome | KRAS G13S [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-6802608] RAS GTPase mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9649641] Rothfels, Karen, 2019-06-14
crossReference	[DatabaseIdentifier:12021093] Mondo:0015075 [DatabaseIdentifier:9649583] COSMIC:COSV55509530
dbId	9649642
disease	[Disease:4791250] colorectal cancer [Disease:1500575] ovarian cancer [Disease:6802256] thyroid carcinoma
displayName	KRAS G13S [plasma membrane]
endCoordinate	186
hasModifiedResidue	[ReplacedResidue:9649564] glycine 13 replaced with L-serine
inDisease	true
literatureReference	[LiteratureReference:9649336] No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cells with multiple KRAS mutations [LiteratureReference:9649360] Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma [LiteratureReference:9649318] Multipoint Kras oncogene mutations potentially indicate mucinous carcinoma on the entire spectrum of mucinous ovarian neoplasms [LiteratureReference:9649259] BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma
maxDepth	1
name	KRAS G13S
referenceEntity	[ReferenceGeneProduct:uniprot:P01116] UniProt:P01116 KRAS
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9649642
startCoordinate	1

(hasCandidate)

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