Reactome | ERBB2 T862A [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 T862A [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9649439] ERBB2 KD mutants (lapatinib) [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9652386] ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane] - Homo sapiens
created	[InstanceEdit:9649440] Orlic-Milacic, Marija, 2019-06-14
crossReference	[DatabaseIdentifier:12021318] Mondo:0004669 [DatabaseIdentifier:9649435] COSMIC:COSV54062276 [DatabaseIdentifier:9649438] COSMIC:COSM6907327
dbId	9649434
disease	[Disease:1500689] cancer [Disease:3310977] small intestine carcinoma [Disease:2327989] bile duct carcinoma [Disease:1493885] bladder carcinoma [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:1614289] melanoma [Disease:1655480] salivary gland cancer [Disease:1500687] stomach cancer
displayName	ERBB2 T862A [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9649437] L-threonine 862 replaced with L-alanine
inDisease	true
literatureReference	[LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2 [LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
maxDepth	1
memberOf	[DefinedSet:R-HSA-9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9649453] Orlic-Milacic, Marija, 2019-06-14
name	ERBB2 T862A ERBB2 Thr862Ala HER2 T862A HER2 Thr862Ala
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9649434
startCoordinate	23

Referrals

(hasComponent)	[Complex:R-HSA-9652386] ERBB2 T862A:ERBIN:HSP90:CDC37 [plasma membrane]
(hasMember)	[CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] [DefinedSet:R-HSA-9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] [CandidateSet:R-HSA-9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [CandidateSet:R-HSA-9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] [CandidateSet:R-HSA-9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-9649439] ERBB2 KD mutants (lapatinib) [plasma membrane]