Reactome | KRAS G12R [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9649091] Rothfels, Karen, 2019-06-10
crossReference	[DatabaseIdentifier:12020779] Mondo:0009831 [DatabaseIdentifier:9649023] COSMIC:COSV55497582
dbId	9649090
disease	[Disease:2328198] pancreatic cancer [Disease:4791250] colorectal cancer [Disease:1500699] lung cancer
displayName	KRAS G12R [plasma membrane]
endCoordinate	186
hasModifiedResidue	[ReplacedResidue:9649083] glycine 12 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:9649020] Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations [LiteratureReference:9649006] Antitumor activity of sorafenib plus CDK4/6 inhibitor in pancreatic patient derived cell with KRAS mutation [LiteratureReference:9649069] Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients
maxDepth	1
memberOf	[CandidateSet:R-HSA-6802608] RAS GTPase mutants [plasma membrane] - Homo sapiens
name	KRAS G12R
referenceEntity	[ReferenceGeneProduct:uniprot:P01116] UniProt:P01116 KRAS
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9649090
startCoordinate	1

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