Reactome | Palmostatin B binds RAS depalmitoylases

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Palmostatin B binds RAS depalmitoylases Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647990] Rothfels, Karen, 2019-06-04
dbId	9647991
displayName	Palmostatin B binds RAS depalmitoylases
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
eventOf	[Pathway:R-HSA-9648002] RAS processing - Homo sapiens
input	[DefinedSet:R-HSA-9647946] LYPLA1 dimer, ABHD17A,B,C [plasma membrane] [ChemicalDrug:R-ALL-9647934] Palmostatin B [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9647869] Small-molecule inhibition of APT1 affects Ras localization and signaling [LiteratureReference:9653267] ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization [LiteratureReference:9647876] Targeting the Ras palmitoylation/depalmitoylation cycle in cancer [LiteratureReference:9653361] Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M [LiteratureReference:9653334] Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design [LiteratureReference:9647859] Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras [LiteratureReference:9653292] Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Palmostatin B binds RAS depalmitoylases
orthologousEvent	[Reaction:R-RNO-9647991] Palmostatin B binds RAS depalmitoylases - Rattus norvegicus [Reaction:R-PFA-9647991] Palmostatin B binds RAS depalmitoylases - Plasmodium falciparum [Reaction:R-SCE-9647991] Palmostatin B binds RAS depalmitoylases - Saccharomyces cerevisiae [Reaction:R-SPO-9647991] Palmostatin B binds RAS depalmitoylases - Schizosaccharomyces pombe [Reaction:R-DDI-9647991] Palmostatin B binds RAS depalmitoylases - Dictyostelium discoideum [Reaction:R-CEL-9647991] Palmostatin B binds RAS depalmitoylases - Caenorhabditis elegans [Reaction:R-DME-9647991] Palmostatin B binds RAS depalmitoylases - Drosophila melanogaster [Reaction:R-GGA-9647991] Palmostatin B binds RAS depalmitoylases - Gallus gallus [Reaction:R-XTR-9647991] Palmostatin B binds RAS depalmitoylases - Xenopus tropicalis [Reaction:R-DRE-9647991] Palmostatin B binds RAS depalmitoylases - Danio rerio [Reaction:R-SSC-9647991] Palmostatin B binds RAS depalmitoylases - Sus scrofa [Reaction:R-BTA-9647991] Palmostatin B binds RAS depalmitoylases - Bos taurus [Reaction:R-CFA-9647991] Palmostatin B binds RAS depalmitoylases - Canis familiaris [Reaction:R-MMU-9647991] Palmostatin B binds RAS depalmitoylases - Mus musculus
output	[Complex:R-HSA-9647947] Palmostatin B:LYPLA1 dimer, ABHD17A,B,C [cytosol]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9647991
summation	[Summation:9653506] Palmostatin B binds to acylthioesterases and inhibits their ...

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(hasEvent)

[Pathway:R-HSA-9648002] RAS processing

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