Reactome | p-6Y-ERBB2 V777L [plasma membrane]

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p-6Y-ERBB2 V777L [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9646581] COSMIC:COSV54062767 [DatabaseIdentifier:9646582] COSMIC:COSM3718346 [DatabaseIdentifier:9646584] COSMIC:COSV54062385
dbId	9647214
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer [Disease:1248674] large intestine cancer [Disease:1500687] stomach cancer [Disease:9632339] esophagus adenocarcinoma [Disease:3310977] small intestine carcinoma [Disease:2328198] pancreatic cancer [Disease:1493885] bladder carcinoma
displayName	p-6Y-ERBB2 V777L [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646580] L-valine 777 replaced with L-leucine [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9646445] Combined Blockade of Activating ERBB2 Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
maxDepth	1
memberOf	[CandidateSet:R-HSA-9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] - Homo sapiens
name	p-6Y-ERBB2 V777L p-6Y-HER2 V777L p-6Y-ERBB2 Val777Leu p-6Y-HER2 Val777Leu
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9647214
startCoordinate	23

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