Reactome | p-6Y-ERBB2 D769Y [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-6Y-ERBB2 D769Y [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:12021320] Mondo:0004192 [DatabaseIdentifier:9646626] COSMIC:COSV54062373 [DatabaseIdentifier:9646635] COSMIC:COSM4422822
dbId	9647199
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:9632339] esophagus adenocarcinoma [Disease:1655480] salivary gland cancer [Disease:1500687] stomach cancer [Disease:9646629] urethra cancer
displayName	p-6Y-ERBB2 D769Y [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646622] L-aspartic acid 769 replaced with L-tyrosine [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9646647] Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface [LiteratureReference:9646787] Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)
maxDepth	1
memberOf	[CandidateSet:R-HSA-9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane] - Homo sapiens
name	p-6Y-ERBB2 D769Y p-6Y-HER2 D769Y p-6Y-ERBB2 Asp769Tyr p-6Y-HER2 Asp769Tyr
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9647199
startCoordinate	23

Referrals

(hasMember)	[CandidateSet:R-HSA-9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] [CandidateSet:R-HSA-9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane]
(hasCandidate)	[CandidateSet:R-HSA-9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane]