Reactome | p-6Y-ERBB2 L755P [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019-05-30
crossReference	[DatabaseIdentifier:12020755] Mondo:0008903 [DatabaseIdentifier:9646496] COSMIC:COSV54069116 [DatabaseIdentifier:9646524] COSMIC:COSM6907352
dbId	9647196
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer
displayName	p-6Y-ERBB2 L755P [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646492] L-leucine 755 replaced with L-proline [ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023 [ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139 [ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196 [ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221 [ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222 [ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease	true
literatureReference	[LiteratureReference:9646493] Atomistic insights into the lung cancer-associated L755P mutation in HER2 resistance to lapatinib: a molecular dynamics study
maxDepth	1
memberOf	[CandidateSet:R-HSA-9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane] - Homo sapiens
name	p-6Y-ERBB2 L755P p-6Y-HER2 L755P p-6Y-ERBB2 Leu755Pro p-6Y-HER2 Leu755Pro
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9647196
startCoordinate	23

(hasMember)

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