Reactome | ERBB2 R896C [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 R896C [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649470] ERBB2 KD mutants (sapitinib) [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9646715] Orlic-Milacic, Marija, 2019-05-28
crossReference	[DatabaseIdentifier:12021303] Mondo:0005580 [DatabaseIdentifier:9646724] COSMIC:COSV54075846
dbId	9646714
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1996318] astrocytoma [Disease:9630862] esophagus squamous cell carcinoma
displayName	ERBB2 R896C [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646716] L-arginine 896 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
maxDepth	1
memberOf	[CandidateSet:R-HSA-9664580] ERBB2 KD mutants (EGFR) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649436] ERBB2 KD mutants (neratinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9646725] Orlic-Milacic, Marija, 2019-05-28
name	ERBB2 R896C HER2 R896C ERBB2 Arg896Cys HER2 Arg896Cys
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9646714
startCoordinate	23

Referrals

(hasCandidate)	[CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] [CandidateSet:R-HSA-9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] [CandidateSet:R-HSA-9649470] ERBB2 KD mutants (sapitinib) [plasma membrane]
(hasMember)	[CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] [CandidateSet:R-HSA-9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [CandidateSet:R-HSA-9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] [CandidateSet:R-HSA-9664580] ERBB2 KD mutants (EGFR) [plasma membrane]