Reactome | ERBB2 V842I [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 V842I [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9649470] ERBB2 KD mutants (sapitinib) [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9646702] Orlic-Milacic, Marija, 2019-05-28
crossReference	[DatabaseIdentifier:12021321] Mondo:0003812 [DatabaseIdentifier:9646706] COSMIC:COSV54062791 [DatabaseIdentifier:9646709] COSMIC:COSM1666633
dbId	9646703
disease	[Disease:1500689] cancer [Disease:9630851] gallbladder adenocarcinoma [Disease:2327989] bile duct carcinoma [Disease:1500576] breast cancer [Disease:2317358] endometrial cancer [Disease:9631134] cervical squamous cell carcinoma [Disease:1248674] large intestine cancer [Disease:9632339] esophagus adenocarcinoma [Disease:1500575] ovarian cancer [Disease:2328198] pancreatic cancer [Disease:1655494] prostate adenocarcinoma [Disease:3310977] small intestine carcinoma [Disease:1500687] stomach cancer [Disease:2327997] pharynx cancer [Disease:1493885] bladder carcinoma [Disease:1655480] salivary gland cancer [Disease:2317371] ovarian endometrioid neoplasm
displayName	ERBB2 V842I [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646701] L-valine 842 replaced with L-isoleucine
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
maxDepth	1
memberOf	[CandidateSet:R-HSA-9665282] ERBB2 KD mutants (lapatinib resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9646718] Orlic-Milacic, Marija, 2019-05-28
name	ERBB2 V842I HER2 V842I ERBB2 Val842Ile HER2 Val842Ile
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9646703
startCoordinate	23

Referrals

(hasMember)

(hasCandidate)

[CandidateSet:R-HSA-9649470] ERBB2 KD mutants (sapitinib) [plasma membrane]