Reactome | ERBB2 V777M [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 V777M [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9646588] Orlic-Milacic, Marija, 2019-05-27
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9646590] COSMIC:COSV54069186 [DatabaseIdentifier:9646592] COSMIC:COSM4775193
dbId	9646591
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer [Disease:1248674] large intestine cancer [Disease:1500687] stomach cancer [Disease:1493885] bladder carcinoma
displayName	ERBB2 V777M [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646587] L-valine 777 replaced with L-methionine
inDisease	true
literatureReference	[LiteratureReference:9647018] Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies [LiteratureReference:9647024] Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas [LiteratureReference:9646931] Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
maxDepth	1
memberOf	[DefinedSet:R-HSA-9649468] ERBB2 KD mutants (trastuzumab) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649458] ERBB2 KD mutants (afatinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649436] ERBB2 KD mutants (neratinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9647027] Orlic-Milacic, Marija, 2019-05-29
name	ERBB2 V777M HER2 V777M ERBB2 Val777Met HER2 Val777Met
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9646591
startCoordinate	23

Referrals

(hasCandidate)	[CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] [CandidateSet:R-HSA-9649470] ERBB2 KD mutants (sapitinib) [plasma membrane] [CandidateSet:R-HSA-9664578] ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-9649468] ERBB2 KD mutants (trastuzumab) [plasma membrane] [CandidateSet:R-HSA-9649439] ERBB2 KD mutants (lapatinib) [plasma membrane] [CandidateSet:R-HSA-9649436] ERBB2 KD mutants (neratinib) [plasma membrane] [CandidateSet:R-HSA-9649458] ERBB2 KD mutants (afatinib) [plasma membrane] [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane]