Reactome | ERBB2 V777L [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

ERBB2 V777L [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9646583] Orlic-Milacic, Marija, 2019-05-27
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:9646581] COSMIC:COSV54062767 [DatabaseIdentifier:9646582] COSMIC:COSM3718346 [DatabaseIdentifier:9646584] COSMIC:COSV54062385
dbId	9646579
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer [Disease:1248674] large intestine cancer [Disease:1500687] stomach cancer [Disease:9632339] esophagus adenocarcinoma [Disease:3310977] small intestine carcinoma [Disease:2328198] pancreatic cancer [Disease:1493885] bladder carcinoma
displayName	ERBB2 V777L [plasma membrane]
endCoordinate	1255
hasModifiedResidue	[ReplacedResidue:9646580] L-valine 777 replaced with L-leucine
inDisease	true
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9646445] Combined Blockade of Activating ERBB2 Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
maxDepth	1
memberOf	[CandidateSet:R-HSA-9649439] ERBB2 KD mutants (lapatinib) [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9665271] ERBB2 KD mutants (AEE788 resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649458] ERBB2 KD mutants (afatinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9665226] ERBB2 KD mutants (trastuzumab resistant) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9649456] ERBB2 KD mutants (osimertinib) [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9646481] ERBB2 KD mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9646619] Orlic-Milacic, Marija, 2019-05-27
name	ERBB2 V777L HER2 V777L ERBB2 Val777Leu HER2 Val777Leu
referenceEntity	[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9646579
startCoordinate	23

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