Reactome | STAT5 Activation

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STAT5 Activation Show undefined attributes

authored	[InstanceEdit:9638040] Varusai, Thawfeek, 2019-02-23
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819469] BioModels Database:BIOMD0000000724 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313 [DatabaseIdentifier:12819649] BioModels Database:BIOMD0000000968
dbId	9645135
displayName	STAT5 Activation
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:261353] response to cytokine
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9645126] Activators bind STAT5 - Homo sapiens [Reaction:R-HSA-9645137] Activator phosphorylates STAT5 - Homo sapiens [Reaction:R-HSA-9645134] p-STAT5 dissociates from activator:STAT5 complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-09-24
literatureReference	[LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	STAT5 Activation
precedingEvent	[BlackBoxEvent:R-HSA-9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 - Homo sapiens [Reaction:R-HSA-9604969] Active FLT3 binds PTPN11 - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9645135
summation	[Summation:9645131] Signal transducer and activator of transcription (STAT) cons...
updateTrackers	[UpdateTracker:9776846] Update Tracker - [Pathway:9645135] STAT5 Activation - v74:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776846] Update Tracker - [Pathway:9645135] STAT5 Activation - v74:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling

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