Reactome | FimH binds D-mannose moiety on host cell

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FimH binds D-mannose moiety on host cell Show undefined attributes

authored	[InstanceEdit:9637715] Stephan, Ralf, 2019-02-19
category	binding
compartment	[Compartment:20798] cell outer membrane [Compartment:876] plasma membrane
created	[InstanceEdit:9638547] Pardo, Agustin, 2019-03-05
crossReference	[DatabaseIdentifier:12020761] Mondo:0005113
dbId	9638571
disease	[Disease:3134792] bacterial infectious disease
displayName	FimH binds D-mannose moiety on host cell
edited	[InstanceEdit:9948470] Stephan, Ralf, 2025-05-21
eventOf	[Pathway:R-HSA-9638630] Attachment of bacteria to epithelial cells - Homo sapiens
input	[DefinedSet:R-HSA-9931995] D-mannose bearing glycoproteins [plasma membrane] [EntityWithAccessionedSequence:R-ECO-9638613] FimH [cell outer membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9638601] In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections [LiteratureReference:9638597] Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding [LiteratureReference:9638654] Direct evidence that the FimH protein is the mannose-specific adhesin of Escherichia coli type 1 fimbriae [LiteratureReference:9932002] Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract [LiteratureReference:9932003] Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives [LiteratureReference:9638614] Catch-bond mechanism of the bacterial adhesin FimH
maxDepth	1
modified	[InstanceEdit:9948469] Stephan, Ralf, 2025-05-21
name	FimH binds D-mannose moiety on host cell
output	[Complex:R-HSA-9932000] FimH:D-mannose bearing glycoproteins [plasma membrane]
previousReviewStatus	[ReviewStatus:9821380] one star
regulatedBy	[NegativeRegulation:9931987] Negative regulation by 'D-mannose [extracellular region]'
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9638571
summation	[Summation:9931988] FimH, as part of type I pili in pathogenic E.coli strains, b...

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(hasEvent)

[Pathway:R-HSA-9638630] Attachment of bacteria to epithelial cells

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