Reactome | HEXB cleaves the terminal GlcNAc from small HA fragments

Schema > Reaction > Entries

HEXB cleaves the terminal GlcNAc from small HA fragments Show undefined attributes

authored	[InstanceEdit:2162221] Jassal, B, 2012-03-16
catalystActivity	[CatalystActivity:9638077] beta-N-acetylhexosaminidase activity of bHEXB [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9638080] Jassal, Bijay, 2019-02-25
dbId	9638076
diseaseReaction	[FailedReaction:R-HSA-9035982] Defective HEXB does not cleave the terminal GalNAc from HA fragments - Homo sapiens
displayName	HEXB cleaves the terminal GlcNAc from small HA fragments
edited	[InstanceEdit:2162221] Jassal, B, 2012-03-16
eventOf	[Pathway:R-HSA-2160916] Hyaluronan degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc - Homo sapiens
input	[OtherEntity:R-ALL-2162223] GlcNAc-GlcA-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605770] Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HEXB cleaves the terminal GlcNAc from small HA fragments
orthologousEvent	[Reaction:R-BTA-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Bos taurus [Reaction:R-DDI-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Dictyostelium discoideum [Reaction:R-CEL-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Caenorhabditis elegans [Reaction:R-GGA-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Gallus gallus [Reaction:R-XTR-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Xenopus tropicalis [Reaction:R-SSC-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Sus scrofa [Reaction:R-CFA-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Canis familiaris [Reaction:R-RNO-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Rattus norvegicus [Reaction:R-MMU-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Mus musculus
output	[SimpleEntity:R-ALL-2162224] GlcA-?1,3-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1678743] GlcNAc [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-2162227] GUSB tetramer hydrolyses (HA)2 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9638076
summation	[Summation:2162222] Beta-hexosaminidase (HEX) cleaves the terminal N-acetyl gala...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9035982] Defective HEXB does not cleave the terminal GalNAc from HA fragments
(hasEvent)	[Pathway:R-HSA-2160916] Hyaluronan degradation
(precedingEvent)	[Reaction:R-HSA-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc