Reactome | NPAS4 binds ARNT2

Schema > Reaction > Entries

NPAS4 binds ARNT2 Show undefined attributes

authored	[InstanceEdit:9770624] Orlic-Milacic, Marija, 2022-04-08
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9634858] Orlic-Milacic, Marija, 2019-01-16
dbId	9634861
displayName	NPAS4 binds ARNT2
edited	[InstanceEdit:9795246] Orlic-Milacic, Marija, 2022-08-02
eventOf	[Pathway:R-HSA-9768919] NPAS4 regulates expression of target genes - Homo sapiens
followingEvent	[Reaction:R-HSA-9769316] NPAS4 binds NAMPT gene promoter - Homo sapiens [Reaction:R-HSA-9768950] NPAS4 binds FOS gene enhancer - Homo sapiens [Reaction:R-HSA-9769419] NPAS4 binds RET gene enhancer - Homo sapiens [Reaction:R-HSA-9644879] NPAS4:ARNT2 binds BDNF gene promoter - Homo sapiens [Reaction:R-HSA-9634884] NPAS4 binds CDK5 gene promoter - Homo sapiens [Reaction:R-HSA-9634886] NPAS4 binds RBFOX3 (NeuN) gene promoter - Homo sapiens [Reaction:R-HSA-9770072] NPAS4 binds SYT10 gene - Homo sapiens [Reaction:R-HSA-9769165] NPAS4 binds PLK2 gene promoter - Homo sapiens [Reaction:R-HSA-9768930] NPAS4 binds MDM2 gene promoter - Homo sapiens [Reaction:R-HSA-9769302] NPAS4 binds INS gene promoter - Homo sapiens [Reaction:R-HSA-9634897] NPAS4 binds CDK5R1 gene promoter - Homo sapiens [Reaction:R-HSA-9769044] NPAS4 binds IQSEC3 gene promoter - Homo sapiens [Reaction:R-HSA-9768939] NPAS4 binds NPAS4 gene enhancer elements - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8936838] ARNT2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9634856] NPAS4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9634848] Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function [LiteratureReference:9634855] Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NPAS4 binds ARNT2
orthologousEvent	[Reaction:R-CEL-9634861] NPAS4 binds ARNT2 - Caenorhabditis elegans [Reaction:R-DME-9634861] NPAS4 binds ARNT2 - Drosophila melanogaster [Reaction:R-XTR-9634861] NPAS4 binds ARNT2 - Xenopus tropicalis [Reaction:R-DRE-9634861] NPAS4 binds ARNT2 - Danio rerio [Reaction:R-SSC-9634861] NPAS4 binds ARNT2 - Sus scrofa [Reaction:R-BTA-9634861] NPAS4 binds ARNT2 - Bos taurus [Reaction:R-CFA-9634861] NPAS4 binds ARNT2 - Canis familiaris [Reaction:R-RNO-9634861] NPAS4 binds ARNT2 - Rattus norvegicus [Reaction:R-MMU-9634861] NPAS4 binds ARNT2 - Mus musculus
output	[Complex:R-HSA-9634849] NPAS4:ARNT2 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9769143] NPAS4 translocates to the nucleus - Homo sapiens
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9795249] Lin, Yingxi, 2022-07-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9634861
summation	[Summation:9634880] NPAS4 is a basic-helix-loop-helix (bHLH) transcription facto...
updateTrackers	[UpdateTracker:9928408] Update Tracker - [Reaction:9634861] NPAS4 binds ARNT2 - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928408] Update Tracker - [Reaction:9634861] NPAS4 binds ARNT2 - v91:[modifyText]
(hasEvent)	[Pathway:R-HSA-9768919] NPAS4 regulates expression of target genes
(precedingEvent)	[Reaction:R-HSA-9769316] NPAS4 binds NAMPT gene promoter [Reaction:R-HSA-9768950] NPAS4 binds FOS gene enhancer [Reaction:R-HSA-9769419] NPAS4 binds RET gene enhancer [Reaction:R-HSA-9644879] NPAS4:ARNT2 binds BDNF gene promoter [Reaction:R-HSA-9634884] NPAS4 binds CDK5 gene promoter [Reaction:R-HSA-9634886] NPAS4 binds RBFOX3 (NeuN) gene promoter [Reaction:R-HSA-9770072] NPAS4 binds SYT10 gene [Reaction:R-HSA-9769165] NPAS4 binds PLK2 gene promoter [Reaction:R-HSA-9768930] NPAS4 binds MDM2 gene promoter [Reaction:R-HSA-9769302] NPAS4 binds INS gene promoter [Reaction:R-HSA-9634897] NPAS4 binds CDK5R1 gene promoter [Reaction:R-HSA-9769044] NPAS4 binds IQSEC3 gene promoter [Reaction:R-HSA-9768939] NPAS4 binds NPAS4 gene enhancer elements

Cite Us!