NPAS4 binds ARNT2

Stable Identifier
R-HSA-9634861
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4 binds ARNT2
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NPAS4 is a basic-helix-loop-helix (bHLH) transcription factor that needs to dimerize with another bHLH protein in order to be able to bind to target DNA. ARNT2 (BMAL2) is a bHLH transcription factor that can form a transcriptionally active heterodimer with NPAS4 (Ooe et al. 2004, Bersten et al. 2014). In vivo, endogenous Arnt2 and Npas4 can be co-immunoprecipitated from the mouse brain (Ooe et al. 2009) and stimulated mouse cortical neurons (Sharma et al. 2019).
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Orthologous Events
NPAS4 binds ARNT2 (Bos taurus)
NPAS4 binds ARNT2 (Caenorhabditis elegans)
NPAS4 binds ARNT2 (Canis familiaris)
NPAS4 binds ARNT2 (Danio rerio)
NPAS4 binds ARNT2 (Drosophila melanogaster)
NPAS4 binds ARNT2 (Mus musculus)
NPAS4 binds ARNT2 (Rattus norvegicus)
NPAS4 binds ARNT2 (Sus scrofa)
NPAS4 binds ARNT2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-01-16)
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