Reactome | CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid

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CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid Show undefined attributes

authored	[InstanceEdit:9616844] May, Bruce, 2018-08-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9634435] May, Bruce, 2019-01-10
dbId	9634433
displayName	CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid
edited	[InstanceEdit:9616844] May, Bruce, 2018-08-14
eventOf	[Pathway:R-HSA-9616222] Transcriptional regulation of granulopoiesis - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9634434] Cebpe gene expression is enhanced by Cebpa - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9616239] CEBPE gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9616845] C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene [LiteratureReference:9616837] C/EBP? overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia [LiteratureReference:9616858] CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing [LiteratureReference:9617069] PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation [LiteratureReference:9622487] C/EBP? participates in all-trans retinoic acid induction of PI3K? in U937 cells via an intronic matrix attachment region sequence [LiteratureReference:9617056] CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment [LiteratureReference:9622459] C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters [LiteratureReference:9622488] Enhancement of differentiation induction and upregulation of CCAAT/enhancer-binding proteins and PU.1 in NB4 cells treated with combination of ATRA and valproic acid
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid
output	[EntityWithAccessionedSequence:R-HSA-3234072] CEBPE [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9616241] CEBPA binds the promoter of the CEBPE gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9616863] Positive gene expression regulation by 'CEBPE gene:CEBPA dimer [nucleoplasm]' [PositiveGeneExpressionRegulation:9617078] Positive gene expression regulation by 'CEBPE gene:EP300:SPI1:PML [nucleoplasm]' [PositiveGeneExpressionRegulation:9617083] Positive gene expression regulation by 'CEBPE gene:RXRA:RARA:atRA [nucleoplasm]'
regulationReference	[RegulationReference:9641250] Positive gene expression regulation by 'CEBPE gene:CEBPA dimer [nucleoplasm]' C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene [RegulationReference:9641837] Positive gene expression regulation by 'CEBPE gene:EP300:SPI1:PML [nucleoplasm]' PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation [RegulationReference:9642091] Positive gene expression regulation by 'CEBPE gene:RXRA:RARA:atRA [nucleoplasm]' CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9634433
summation	[Summation:9622445] CEBPE is expressed exclusively in myeloid progenitor cells a...

Referrals

(hasEvent)	[Pathway:R-HSA-9616222] Transcriptional regulation of granulopoiesis
(inferredTo)	[BlackBoxEvent:R-MMU-9634434] Cebpe gene expression is enhanced by Cebpa

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