Reactome | CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid

CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid

Stable Identifier

R-HSA-9634433

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid

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CEBPE is expressed exclusively in myeloid progenitor cells and is required for terminal differentiation of granulocyte precursors. Transcription of CEBPE is activated by at least 3 mechanisms:
1) CEBPA dimers bound to the promoter of CEBPE (Yamanaka et al. 1997, Matusushita et al. 2008, Loke et al. 2018, and inferred from mouse homologs),
2) SPI1 (PU.1), PML. and EP300 bound to the promoter of CEBPE (Yoshida et al. 2007), and
3) retinoic acid activation of the RARA:RXR retinoic acid receptor bound to the CEBPE promoter (Park et al. 1999, Verbeek et al. 1999, Cai et al. 2010, Iriyama et al. 2014). Activation of CEBPE by retinoic acid is believed to ameliorate some cases of leukemia (Park et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
18776924	C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene Matsushita, H, Nakajima, H, Nakamura, Y, Tsukamoto, H, Tanaka, Y, Jin, G, Yabe, M, Asai, S, Ono, R, Nosaka, T, Sugita, K, Morimoto, A, Hayashi, Y, Hotta, T, Ando, K, Miyachi, H	Oncogene	2008
17562868	PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation Yoshida, H, Ichikawa, H, Tagata, Y, Katsumoto, T, Ohnishi, K, Akao, Y, Naoe, T, Pandolfi, PP, Kitabayashi, I	Mol. Cell. Biol.	2007
24379003	Enhancement of differentiation induction and upregulation of CCAAT/enhancer-binding proteins and PU.1 in NB4 cells treated with combination of ATRA and valproic acid Iriyama, N, Yuan, B, Yoshino, Y, Hatta, Y, Horikoshi, A, Aizawa, S, Takei, M, Takeuchi, J, Takagi, N, Toyoda, H	Int. J. Oncol.	2014
10233885	C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters Verbeek, W, Gombart, AF, Chumakov, AM, Müller, C, Friedman, AD, Koeffler, HP	Blood	1999
9177240	CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing Yamanaka, R, Kim, GD, Radomska, HS, Lekstrom-Himes, J, Smith, LT, Antonson, P, Tenen, DG, Xanthopoulos, KG	Proc. Natl. Acad. Sci. U.S.A.	1997
29431622	C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia Loke, J, Chin, PS, Keane, P, Pickin, A, Assi, SA, Ptasinska, A, Imperato, MR, Cockerill, PN, Bonifer, C	Blood Adv	2018
20661648	C/EBPε participates in all-trans retinoic acid induction of PI3Kγ in U937 cells via an intronic matrix attachment region sequence Cai, R, Cai, X, Chen, B, Xu, W, Lu, J	Mol. Biol. Rep.	2010
10330422	CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment Park, DJ, Chumakov, AM, Vuong, PT, Chih, DY, Gombart, AF, Miller, WH, Koeffler, HP	J. Clin. Invest.	1999