Reactome | ERBB2 homodimer phosphorylates SHC1

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ERBB2 homodimer phosphorylates SHC1 Show undefined attributes

authored	[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019-07-31
catalystActivity	[CatalystActivity:9634396] protein tyrosine kinase activity of p-ERBB2 homodimer:SHC1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9634387] Orlic-Milacic, Marija, 2019-01-10
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9634390
disease	[Disease:1500689] cancer
displayName	ERBB2 homodimer phosphorylates SHC1
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9655466] increased_translational_product_level of p-ERBB2 homodimer:SHC1 [plasma membrane]
eventOf	[Pathway:R-HSA-9634285] Constitutive Signaling by Overexpressed ERBB2 - Homo sapiens
followingEvent	[Reaction:R-HSA-9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9634389] p-ERBB2 homodimer:SHC1 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 homodimer phosphorylates SHC1
normalReaction	[Reaction:R-HSA-1250195] SHC1 phosphorylation by ERBB2 heterodimers
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9634399] p-ERBB2 homodimer:p-Y349,Y350-SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9634391] SHC1 binds phosphorylated ERBB2 homodimer - Homo sapiens
releaseDate	2019-12-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9662685] Kancha, Rama Krishna, 2019-09-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9634390
summation	[Summation:9634405] While phosphorylation of SHC1 upon binding to homodimers of ...

Referrals

(hasEvent)	[Pathway:R-HSA-9634285] Constitutive Signaling by Overexpressed ERBB2
(precedingEvent)	[Reaction:R-HSA-9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer

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