ERBB2 homodimer phosphorylates SHC1

Stable Identifier
R-HSA-9634390
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

While phosphorylation of SHC1 upon binding to homodimers of overexpressed ERBB2 has not been tested, it is assumed, based on SHC1 binding and downstream activation of RAS signaling (Pickl and Ries 2009), that ERBB2 homodimers, similar to ERBB2 heterodimers, phosphorylate SHC1, enabling it to recruit GRB2:SOS1 complex and activate downstream RAS/RAF/MAPK signaling.

Literature References
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of p-ERBB2 homodimer:SHC1 [plasma membrane]

Normal reaction
Functional status

Increased translational product level of p-ERBB2 homodimer:SHC1 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
Cite Us!