ERBB2 homodimer phosphorylates SHC1

Stable Identifier
R-HSA-9634390
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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While phosphorylation of SHC1 upon binding to homodimers of overexpressed ERBB2 has not been tested, it is assumed, based on SHC1 binding and downstream activation of RAS signaling (Pickl and Ries 2009), that ERBB2 homodimers, similar to ERBB2 heterodimers, phosphorylate SHC1, enabling it to recruit GRB2:SOS1 complex and activate downstream RAS/RAF/MAPK signaling.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-ERBB2 homodimer:SHC1 [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created