Reactome | HSPA8 transports unfolded substrate to lysosomal lumen for degradation

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HSPA8 transports unfolded substrate to lysosomal lumen for degradation Show undefined attributes

authored	[InstanceEdit:9637871] Varusai, Thawfeek, 2019-02-21
category	transition
compartment	[Compartment:161320] lysosomal lumen [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9625192] Varusai, Thawfeek, 2018-10-19
dbId	9625188
displayName	HSPA8 transports unfolded substrate to lysosomal lumen for degradation
edited	[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
eventOf	[Pathway:R-HSA-9613829] Chaperone Mediated Autophagy - Homo sapiens
followingEvent	[Reaction:R-HSA-9626060] HSPA8:Substrate dissociates from LAMP2a multimer - Homo sapiens
inferredFrom	[Reaction:R-RNO-9625160] Hspa8 transports unfolded substrate to lysosomal lumen for degradation - Rattus norvegicus
input	[Complex:R-HSA-9625165] HSPA8:LAMP2a multimeric complex [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9625186] A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins [LiteratureReference:9625187] An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HSPA8 transports unfolded substrate to lysosomal lumen for degradation
output	[Complex:R-HSA-9625189] HSPA8:LAMP2a multimeric complex [lysosomal membrane]
precedingEvent	[Reaction:R-HSA-9625196] Unfolded substrate in LAMP2a multimeric complex binds HSPA8 - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637993] Metzakopian, Emmanouil, 2019-02-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9625188
summation	[Summation:9625162] Heat shock cognate 71 kDa protein (HSPA8) translocates subst...

Referrals

(hasEvent)	[Pathway:R-HSA-9613829] Chaperone Mediated Autophagy
(precedingEvent)	[Reaction:R-HSA-9626060] HSPA8:Substrate dissociates from LAMP2a multimer
(inferredTo)	[Reaction:R-RNO-9625160] Hspa8 transports unfolded substrate to lysosomal lumen for degradation

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