HSPA8 transports unfolded substrate to lysosomal lumen for degradation

Stable Identifier
R-HSA-9625188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal lumen, lysosomal membrane
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HSPA8 transports unfolded substrate to lysosomal lumen for degradation
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Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from the cytosol to the lysosomal membrane. Subsequently, the substrate unfolds and binds to HSPA8 in the lysosomal lumen. HSPA8 facilitates the transport of the unfolded substrate to the lumen where it is then degraded (Agarraberes FA et al. 1997, Cuervo AM et al. 1997).

Literature References
PubMed ID Title Journal Year
9038169 A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

Cuervo, AM, Dice, JF, Knecht, E

J. Biol. Chem. 1997
9151685 An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

Agarraberes, FA, Terlecky, SR, Dice, JF

J. Cell Biol. 1997
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Hspa8 transports unfolded substrate to lysosomal lumen for degradation (Rattus norvegicus)
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-10-19)
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