HSPA8 transports unfolded substrate to lysosomal lumen for degradation

Stable Identifier
R-HSA-9625188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal lumen, lysosomal membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HSPA8 transports unfolded substrate to lysosomal lumen for degradation
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Heat shock cognate 71 kDa protein (HSPA8) translocates substrates from the cytosol to the lysosomal membrane. Subsequently, the substrate unfolds and binds to HSPA8 in the lysosomal lumen. HSPA8 facilitates the transport of the unfolded substrate to the lumen where it is then degraded (Agarraberes FA et al. 1997, Cuervo AM et al. 1997).

Literature References
PubMed ID Title Journal Year
9038169 A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

Cuervo, AM, Dice, JF, Knecht, E

J. Biol. Chem. 1997
9151685 An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

Agarraberes, FA, Terlecky, SR, Dice, JF

J. Cell Biol. 1997
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Hspa8 transports unfolded substrate to lysosomal lumen for degradation (Rattus norvegicus)
Authored
Varusai, TM  (2019-02-21)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-10-19)