Reactome | CDK1 phosphorylates LBR

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CDK1 phosphorylates LBR Show undefined attributes

authored	[InstanceEdit:9667932] Gerace, Larry, 2019-11-07
catalystActivity	[CatalystActivity:2311326] cyclin-dependent protein serine/threonine kinase activity of CCNB1,CCNB2:p-T161-CDK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:9624802] Orlic-Milacic, Marija, 2018-10-15
dbId	9624800
displayName	CDK1 phosphorylates LBR
edited	[InstanceEdit:9668537] Orlic-Milacic, Marija, 2019-11-26
eventOf	[Pathway:R-HSA-2995383] Initiation of Nuclear Envelope (NE) Reformation - Homo sapiens
followingEvent	[Reaction:R-HSA-9624798] LBR binds KPNB1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-194637] LBR [nuclear envelope]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9624796] Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CDK1 phosphorylates LBR
orthologousEvent	[Reaction:R-BTA-9624800] CDK1 phosphorylates LBR - Bos taurus [Reaction:R-DME-9624800] CDK1 phosphorylates LBR - Drosophila melanogaster [Reaction:R-GGA-9624800] CDK1 phosphorylates LBR - Gallus gallus [Reaction:R-XTR-9624800] CDK1 phosphorylates LBR - Xenopus tropicalis [Reaction:R-DRE-9624800] CDK1 phosphorylates LBR - Danio rerio [Reaction:R-SSC-9624800] CDK1 phosphorylates LBR - Sus scrofa [Reaction:R-CFA-9624800] CDK1 phosphorylates LBR - Canis familiaris [Reaction:R-RNO-9624800] CDK1 phosphorylates LBR - Rattus norvegicus [Reaction:R-MMU-9624800] CDK1 phosphorylates LBR - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-9624811] p-S71,S86-LBR [nuclear envelope]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9624800
summation	[Summation:9624810] During mitosis, CDK1 phosphorylates LBR (lamin B receptor) o...

Referrals

(hasEvent)	[Pathway:R-HSA-2995383] Initiation of Nuclear Envelope (NE) Reformation
(precedingEvent)	[Reaction:R-HSA-9624798] LBR binds KPNB1