Reactome | CEBPA binds MYC gene:E2F1

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CEBPA binds MYC gene:E2F1 Show undefined attributes

authored	[InstanceEdit:9618589] May, Bruce, 2018-09-10
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9618578] May, Bruce, 2018-09-10
dbId	9618582
displayName	CEBPA binds MYC gene:E2F1
edited	[InstanceEdit:9618589] May, Bruce, 2018-09-10
eventOf	[Pathway:R-HSA-9616222] Transcriptional regulation of granulopoiesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9634445] MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA - Homo sapiens
inferredFrom	[Reaction:R-MMU-9625589] Cebpa binds Myc gene:E2f1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-381289] CEBPA [nucleoplasm] [Complex:R-HSA-9617780] MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9618580] c-Myc is a critical target for c/EBPalpha in granulopoiesis [LiteratureReference:9617810] The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells [LiteratureReference:9625595] Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CEBPA binds MYC gene:E2F1
output	[Complex:R-HSA-9617790] MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9618586] E2F1 binds the promoter of the MYC gene - Homo sapiens [BlackBoxEvent:R-HSA-9622367] CEBPA mRNA is translated to yield CEBPA protein - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9639377] Skokowa, Julia, 2019-03-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9618582
summation	[Summation:9624065] CEBPA interacts with E2F1 (Keeshan et al. 2003) bound to the...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9634445] MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA
(hasEvent)	[Pathway:R-HSA-9616222] Transcriptional regulation of granulopoiesis
(inferredTo)	[Reaction:R-MMU-9625589] Cebpa binds Myc gene:E2f1

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