Reactome | CEBPA binds MYC gene:E2F1

CEBPA binds MYC gene:E2F1

Stable Identifier

R-HSA-9618582

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CEBPA interacts with E2F1 (Keeshan et al. 2003) bound to the promoter of the MYC gene (Johansen et al. 2001, D'Alo' et al.2003, also inferred from mouse homologs). CEBPA inhibits the transcriptional activation activity of E2F1 and inhibits transcription of MYC. By inhibiting MYC, CEBPA inhibits cell proliferation and promotes differentiation (Johansen et al. 2001, D'Alo' et al. 2003). The N terminus of the p42 isoform of CEBPA is required for interaction with E2F factors (inferred from mouse homologs) and therefore the p30 isoform, which lacks the N terminus, has a reduced ability to inhibit proliferation.

Literature References

PubMed ID	Title	Journal	Year
12702500	Transcription activation function of C/EBPalpha is required for induction of granulocytic differentiation Keeshan, K, Santilli, G, Corradini, F, Perrotti, D, Calabretta, B	Blood	2003
11340171	c-Myc is a critical target for c/EBPalpha in granulopoiesis Johansen, LM, Iwama, A, Lodie, TA, Sasaki, K, Felsher, DW, Golub, TR, Tenen, DG	Mol. Cell. Biol.	2001
12869508	The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells D'Alo', F, Johansen, LM, Nelson, EA, Radomska, HS, Evans, EK, Zhang, P, Nerlov, C, Tenen, DG	Blood	2003