Reactome | PEX19:class I PMP binds PEX3

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PEX19:class I PMP binds PEX3 Show undefined attributes

authored	[InstanceEdit:9603786] May, Bruce, 2018-03-19
category	binding
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9603789] May, Bruce, 2018-03-24
dbId	9603784
displayName	PEX19:class I PMP binds PEX3
edited	[InstanceEdit:9603786] May, Bruce, 2018-03-19
eventOf	[Pathway:R-HSA-9603798] Class I peroxisomal membrane protein import - Homo sapiens
followingEvent	[Reaction:R-HSA-9603775] PEX3:PEX19:class I PMP dissociates - Homo sapiens
input	[Complex:R-HSA-9603787] PEX19:class I PMP [cytosol] [EntityWithAccessionedSequence:R-HSA-382608] PEX3 [peroxisomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:382607] PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins [LiteratureReference:9604117] Identification and characterization of the human peroxin PEX3 [LiteratureReference:9604071] The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis [LiteratureReference:9604115] In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p [LiteratureReference:9604120] Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation [LiteratureReference:9603844] The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step [LiteratureReference:9604079] The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis [LiteratureReference:9604118] Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p [LiteratureReference:9604084] Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19 [LiteratureReference:9604106] Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction [LiteratureReference:9603861] Assembly of Peroxisomal Membrane Proteins via the Direct Pex19p-Pex3p Pathway [LiteratureReference:9604122] Association between the intrinsically disordered protein PEX19 and PEX3 [LiteratureReference:9635354] Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PEX19:class I PMP binds PEX3
orthologousEvent	[Reaction:R-SCE-9603784] PEX19:class I PMP binds PEX3 - Saccharomyces cerevisiae [Reaction:R-SPO-9603784] PEX19:class I PMP binds PEX3 - Schizosaccharomyces pombe [Reaction:R-DDI-9603784] PEX19:class I PMP binds PEX3 - Dictyostelium discoideum [Reaction:R-CEL-9603784] PEX19:class I PMP binds PEX3 - Caenorhabditis elegans [Reaction:R-DME-9603784] PEX19:class I PMP binds PEX3 - Drosophila melanogaster [Reaction:R-GGA-9603784] PEX19:class I PMP binds PEX3 - Gallus gallus [Reaction:R-XTR-9603784] PEX19:class I PMP binds PEX3 - Xenopus tropicalis [Reaction:R-DRE-9603784] PEX19:class I PMP binds PEX3 - Danio rerio [Reaction:R-SSC-9603784] PEX19:class I PMP binds PEX3 - Sus scrofa [Reaction:R-BTA-9603784] PEX19:class I PMP binds PEX3 - Bos taurus [Reaction:R-CFA-9603784] PEX19:class I PMP binds PEX3 - Canis familiaris [Reaction:R-RNO-9603784] PEX19:class I PMP binds PEX3 - Rattus norvegicus [Reaction:R-MMU-9603784] PEX19:class I PMP binds PEX3 - Mus musculus
output	[Complex:R-HSA-9603793] PEX3:PEX19:class I PMP [peroxisomal membrane]
precedingEvent	[Reaction:R-HSA-9603804] PEX19 binds class I peroxisomal membrane proteins - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9635347] Fransen, Marc, 2019-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9603784
summation	[Summation:9604066] Cytosolic PEX19 bound to a peroxisomal membrane protein bind...

Referrals

(precedingEvent)	[Reaction:R-HSA-9603775] PEX3:PEX19:class I PMP dissociates
(hasEvent)	[Pathway:R-HSA-9603798] Class I peroxisomal membrane protein import

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