PEX19:class I PMP binds PEX3

Stable Identifier
Reaction [binding]
Homo sapiens
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Cytosolic PEX19 bound to a peroxisomal membrane protein binds PEX3 which is located in the peroxisomal membrane and serves as a docking receptor for PEX19 (Soukupova et al. 1999, Muntau et al. 2003, Fang et al. 2004, Matsuzono and Fujiki 2006, Matsuzono et al. 2006, Pinto et al. 2006, Sato et al. 2008, Sato et al. 2010, Schmidt et al. 2010, Hattula et al. 2014, reviewed in Fujiki et al. 2006). PEX19 bound to a cargo protein has much higher affinity for PEX3 than PEX19 alone does (Pinto et al. 2006). The insertion of the peroxisomal membrane protein into the membrane does not require ATP hydrolysis or GTP hydrolysis (Pinto et al. 2006). The N-terminal region of PEX19 binds a hydrophobic groove and acidic cluster on the surface of PEX3 (Schmidt et al. 2010, Schmidt et al. 2012) at the cytosolic apex of the PEX3 spheroid (Sato et al. 2010).

Literature References
PubMed ID Title Journal Year
22624858 The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis

Dietrich, D, Stehle, T, Groemping, Y, Schmidt, F, Eylenstein, R, Dodt, G

Traffic 2012
18174172 Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction

Sato, Y, Kobayashi, Y, Matsuzono, Y, Nakano, H, Kashiwayama, Y, Shibata, H, Kato, H, Imanaka, T, Fujiki, Y

J. Biol. Chem. 2008
16980692 The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step

Sá-Miranda, C, Oliveira, ME, Grou, CP, Alencastre, IS, Azevedo, JE, Pinto, MP, Fransen, M

J. Biol. Chem. 2006
12924628 The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis

Roscher, AA, Kunau, WH, Muntau, AC, Dodt, G

Eur. J. Cell Biol. 2003
16895967 Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation

Matsuzaki, T, Matsuzono, Y, Fujiki, Y

J. Cell. Sci. 2006
15007061 PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins

Fang, Y, Jones, JM, Gould, SJ, Morrell, JC

J Cell Biol 2004
17069900 Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions

Matsuzaki, T, Matsuzono, Y, Fransen, M, Fujiki, Y

Biochim. Biophys. Acta 2006
25062251 Association between the intrinsically disordered protein PEX19 and PEX3

Ora, A, Butcher, SJ, Hirschberg, D, Hattula, K, Kalkkinen, N

PLoS ONE 2014
26777132 Assembly of Peroxisomal Membrane Proteins via the Direct Pex19p-Pex3p Pathway

Yagita, Y, Liu, Y, Fujiki, Y

Traffic 2016
10430017 Identification and characterization of the human peroxin PEX3

Kunau, WH, Gorgas, K, Sprenger, C, Soukupova, M, Dodt, G

Eur. J. Cell Biol. 1999
20554521 Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19

Steinmetz, MO, Treiber, N, Bjelic, S, Kalbacher, H, Stehle, T, Zocher, G, Schmidt, F, Dodt, G

J. Biol. Chem. 2010
21102411 Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p

Sato, Y, Nakano, H, Nakatsu, T, Kashiwayama, Y, Shibata, H, Kato, H, Imanaka, T

EMBO J. 2010
16280322 In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p

Matsuzono, Y, Fujiki, Y

J. Biol. Chem. 2006
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