Reactome | PEX19:class I PMP binds PEX3

PEX19:class I PMP binds PEX3

Stable Identifier

R-HSA-9603784

Type

Reaction [binding]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic PEX19 bound to a peroxisomal membrane protein binds PEX3 which is located in the peroxisomal membrane and serves as a docking receptor for PEX19 (Soukupova et al. 1999, Muntau et al. 2003, Fang et al. 2004, Matsuzono and Fujiki 2006, Matsuzono et al. 2006, Pinto et al. 2006, Sato et al. 2008, Sato et al. 2010, Schmidt et al. 2010, Hattula et al. 2014, reviewed in Fujiki et al. 2006). PEX19 bound to a cargo protein has much higher affinity for PEX3 than PEX19 alone does (Pinto et al. 2006). The insertion of the peroxisomal membrane protein into the membrane does not require ATP hydrolysis or GTP hydrolysis (Pinto et al. 2006). The N-terminal region of PEX19 binds a hydrophobic groove and acidic cluster on the surface of PEX3 (Schmidt et al. 2010, Schmidt et al. 2012) at the cytosolic apex of the PEX3 spheroid (Sato et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
22624858	The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis Schmidt, F, Dietrich, D, Eylenstein, R, Groemping, Y, Stehle, T, Dodt, G	Traffic	2012
18174172	Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction Sato, Y, Shibata, H, Nakano, H, Matsuzono, Y, Kashiwayama, Y, Kobayashi, Y, Fujiki, Y, Imanaka, T, Kato, H	J. Biol. Chem.	2008
16980692	The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step Pinto, MP, Grou, CP, Alencastre, IS, Oliveira, ME, Sá-Miranda, C, Fransen, M, Azevedo, JE	J. Biol. Chem.	2006
12924628	The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis Muntau, AC, Roscher, AA, Kunau, WH, Dodt, G	Eur. J. Cell Biol.	2003
16895967	Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation Matsuzono, Y, Matsuzaki, T, Fujiki, Y	J. Cell. Sci.	2006
15007061	PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins Fang, Y, Morrell, JC, Jones, JM, Gould, SJ	J Cell Biol	2004
17069900	Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions Fujiki, Y, Matsuzono, Y, Matsuzaki, T, Fransen, M	Biochim. Biophys. Acta	2006
25062251	Association between the intrinsically disordered protein PEX19 and PEX3 Hattula, K, Hirschberg, D, Kalkkinen, N, Butcher, SJ, Ora, A	PLoS ONE	2014
26777132	Assembly of Peroxisomal Membrane Proteins via the Direct Pex19p-Pex3p Pathway Liu, Y, Yagita, Y, Fujiki, Y	Traffic	2016
10430017	Identification and characterization of the human peroxin PEX3 Soukupova, M, Sprenger, C, Gorgas, K, Kunau, WH, Dodt, G	Eur. J. Cell Biol.	1999
20554521	Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19 Schmidt, F, Treiber, N, Zocher, G, Bjelic, S, Steinmetz, MO, Kalbacher, H, Stehle, T, Dodt, G	J. Biol. Chem.	2010
21102411	Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p Sato, Y, Shibata, H, Nakatsu, T, Nakano, H, Kashiwayama, Y, Imanaka, T, Kato, H	EMBO J.	2010
16280322	In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p Matsuzono, Y, Fujiki, Y	J. Biol. Chem.	2006