Reactome | p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]

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p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2262777] TRAF6 binds to p-IRAK2 - Homo sapiens
created	[InstanceEdit:937065] Shamovsky, V, 2010-08-25
dbId	937055
displayName	p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
hasComponent	4 × [EntityWithAccessionedSequence:R-HSA-936949] p-IRAK2 [plasma membrane] [Complex:R-HSA-937048] p-S,2T-IRAK4:oligo-MyD88:TIRAP:activated TLR receptor [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
literatureReference	[LiteratureReference:937049] Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling [LiteratureReference:571295] Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
maxDepth	10
modified	[InstanceEdit:9615894] Shamovsky, Veronica, 2018-08-09
name	p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR
producedByEvent	[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex - Homo sapiens
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-937055
updateTrackers	[UpdateTracker:9895063] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9872522] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9892898] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v54:[updateContainedComponent] [UpdateTracker:9873018] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9871210] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9870641] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v38:[updateContainedComponent] [UpdateTracker:9899811] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9895997] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v60:[removeSpecies, updateContainedComponent] [UpdateTracker:9889854] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v52:[updateContainedComponent] [UpdateTracker:9874539] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9889391] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v49:[updateContainedComponent] [UpdateTracker:9899572] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v66:[modifyName, updateContainedComponent] [UpdateTracker:9902044] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v76:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9895063] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v59:[updateContainedComponent] [UpdateTracker:9872522] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v41:[updateContainedComponent] [UpdateTracker:9892898] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v54:[updateContainedComponent] [UpdateTracker:9873018] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v42:[addLiteratureReference, updateContainedComponent] [UpdateTracker:9871210] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v39:[updateContainedComponent] [UpdateTracker:9870641] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v38:[updateContainedComponent] [UpdateTracker:9899811] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v67:[updateContainedComponent] [UpdateTracker:9895997] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v60:[removeSpecies, updateContainedComponent] [UpdateTracker:9889854] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v52:[updateContainedComponent] [UpdateTracker:9874539] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v43:[updateContainedComponent] [UpdateTracker:9889391] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v49:[updateContainedComponent] [UpdateTracker:9899572] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v66:[modifyName, updateContainedComponent] [UpdateTracker:9902044] Update Tracker - [Complex:937055] p-IRAK2:p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane] - v76:[updateContainedComponent]
(input)	[Reaction:R-HSA-2262777] TRAF6 binds to p-IRAK2
(hasComponent)	[Complex:R-HSA-2262774] TRAF6:p-IRAK2 :p-IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
(output)	[Reaction:R-HSA-937059] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex

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